Our investigate will involve: one) stem cell technologies centered on restoring sight in individuals with macular degeneration and various retinal ailments along with glaucoma and a pair of) cell shipping and delivery systems to transplant useful cells to suitable places.
I am interested in the purification of dopamine neurons from embryonic stem cells and also the reprogramming of human somatic cells to pluripotent stem cells.
For these experiments, we use equally the zebrafish and mouse styles Along with the hope to understand how this process goes Erroneous for the duration of delivery defects and disease.
An illustration of an acute knee injuries is usually a skier or golfer that has hurt a knee ligament or meniscus and desires to recover efficiently and obtain again for their preferred sport speedily.
My team is investigating the job of cell adhesion molecules and cell adhesion molecule-mediated signaling in most cancers stem cells. Our key concentration is non-melanoma pores and skin most cancers.
Former aggressive tennis player and skier, with degeneration of soft tissue and arthritic modifications within the knee, uses stem cell injections as an alternative to knee replacement surgical treatment.*
Specifically, we deal with the establishing cerebral cortex And just how differing kinds of projection neurons and glial cells are specified from cortical progenitor cells.
The Herson laboratory investigates the acute and prolonged-time period sequelae of obtained brain injuries. Clicking Here The laboratory takes advantage of experimental types of ischemic stroke, cardiac arrest/CPR, and traumatic Mind harm to evaluate histological and functional outcomes pursuing personal injury.
Our do the job focuses on how inflammation regulates the destiny options of blood-forming hematopoietic stem cells. We also examine how Serious inflammation can deregulate HSC destiny pathways to worsen illness, and strategies to restore normal HSC perform During this context.
Our group is centered on comprehension depigmentation and repigmentation in human vitiligo, a condition that affects the entire world's populace, creating sizeable social and psychological complications in all individuals.
2. Manipulating cardiomyogenesis or cardiac lineage reprogramming with tiny molecules. While we as well as other investigators have proven that fibroblasts is often reprogrammed towards a cardiac cell destiny, the performance is very minimal.
We anchor hypothesize that leukemia stem cells sustain self-renewal properties nevertheless aberrant expression of stem cell systems managed by epigenetic mechanisms. Targeted modulation of the epigenetic modifiers that control stem cell courses could serve as new approach to most cancers therapy.
The extensive-phrase target of our investigation would be to determine the molecular and cellular mechanisms by which neural stem cells are instructed to produce the large number of cell varieties needed to next page create a adequately functioning brain.
Our lab is centered on elucidating the developmental origins of such many cell styles to uncover the mechanisms by which cortical circuits are assembled. This investigation will offer insights in to the pathologies of quite a few neurological disorders and cause a better idea of tips on how to effectively create specific cell forms for stem cell therapy methods.